In order to solve the problem of tight mining succession in single wing mining mines, there is often a situation of opposite excavation when facing the mining face. During the excavation of the mining face, the law of rock pressure manifestation and the width of the coal pillar are the key to ensuring the safe mining of the tunnel excavation and working face. Taking the 100303 transportation roadway of a certain mine as the engineering background, theoretical analysis, numerical simulation, on-site monitoring and other methods were used to study the reasonable width of coal pillars and the law of rock pressure behavior during the excavation period. The main conclusion is that through theoretical calculation, under the dual influence of excavation disturbance and working face mining, the width that ensures the existence of elastic core and incomplete plastic failure of the coal pillar is at least 30m. Numerical simulations have found that when the heading of the excavation is 20~30m ahead of the meeting position, the deformation of the surrounding rock increases, and the deformation of the coal pillar and mining side both exceeds 0.5m. When the excavation reaches a certain distance behind the goaf, the deformation of the surrounding rock is accelerated due to the combined influence of excavation disturbance and lateral support stress in the goaf, resulting in severe deformation of the coal pillar wall, with a maximum deformation exceeding 1m. When the excavation distance of the 100303 transportation roadway is 70m from the 100302 fully mechanized mining face, the excavation should be stopped, and the support parameters should be optimized within the disturbance range to improve the bearing capacity of the coal pillar. On site monitoring shows that the deformation of the top, bottom, and two sides of the tunnel is relatively small and within a controllable range, effectively controlling the deformation of the surrounding rock of the excavation face in the face of mining.